Gwozdzinski K
Physiol Chem Phys Med NMR. 1985;17(4):431-4.
The addition of cupric ions caused decreased permeability to hydrophilic molecules and increased permeability to hydrophobic molecules. These results suggest that TEMPOL penetrates the erythrocyte in a different way than TEMPO. Penetration of TEMPOL is controlled by-SH groups, while TEMPO probably diffuses through the lipid bilayer. Cupric ions increase the permeability of erythrocyte membranes to both non-electrolytes in vivo.
铜离子的添加导致对亲水分子的通透性降低，对疏水分子的通透性增加。这些结果表明，TEMPOL穿透红细胞的方式与TEMPO不同。TEMPOL的穿透受-SH基团控制，而TEMPO可能通过脂质双层扩散。铜离子增加了红细胞膜对体内两种非电解质的通透性。
