Hiltunen A J, Järbe T U
Psychopharmacology (Berl). 1986;89(3):284-90. doi: 10.1007/BF00174360.
Separate groups of gerbils were trained in a T-maze to discriminate between either: (1) the 1,4-benzodiazepine Ro 11-6896 (1 mg/kg), (2) chlordiazepoxide (25 mg/kg) or (3) ethanol (2,000 mg/kg) and vehicle. Thus, the respective training condition served as a discriminative stimulus guiding choice behavior. A degree of generalization which was enhanced by increasing injection-test intervals occurred between ethanol and the benzodiazepines. Ro 15-1788 markedly attenuated the cue properties of the benzodiazepines, but not that of ethanol. Additional tests in the Ro 11-6896 group showed that this discrimination was stereoselective but not stereospecific in that the isomer Ro 11-6893 generalized to Ro 11-6896 at a dose of 10 mg/kg but not at 1 mg/kg; Ro 15-1788 attenuated this generalization. Diazepam (3 mg/kg) generalized to Ro 11-6896 whereas the structurally related Ro 5-4864 (3 mg/kg and 30 mg/kg) did not. In separate tests of open-field activity and temperature recording Ro 15-1788 significantly attenuated the effects of Ro 11-6896 (1 mg/kg) and Ro 11-6893 (10 mg/kg).
将不同组的沙鼠置于T型迷宫中进行训练，以区分以下几种情况：(1) 1,4-苯二氮䓬Ro 11-6896（1毫克/千克），(2) 氯氮䓬（25毫克/千克），或(3) 乙醇（2000毫克/千克）与赋形剂。因此，相应的训练条件作为一种辨别性刺激来引导选择行为。乙醇与苯二氮䓬之间存在一定程度的泛化，这种泛化通过增加注射-测试间隔而增强。Ro 15-1788显著减弱了苯二氮䓬的提示特性，但对乙醇的提示特性没有影响。在Ro 11-6896组进行的额外测试表明，这种辨别具有立体选择性但不具有立体特异性，因为异构体Ro 11-6893在剂量为10毫克/千克时能泛化到Ro 11-6896，但在1毫克/千克时则不能；Ro 15-1788减弱了这种泛化。地西泮（3毫克/千克）能泛化到Ro 11-6896，而结构相关的Ro 5-4864（3毫克/千克和30毫克/千克）则不能。在旷场活动和体温记录的单独测试中，Ro 15-1788显著减弱了Ro 11-6896（1毫克/千克）和Ro
