Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, One-Gustave L. Levy Place, New York, NY 10029, USA.
Infect Dis Clin North Am. 2018 Sep;32(3):651-666. doi: 10.1016/j.idc.2018.04.005.
Invasive candidiasis (IC) remains the most common invasive fungal infection following solid-organ transplant (SOT), but risk factors are evolving. Current challenges include infection due to drug resistant non-albicans and emerging novel species such as Candida auris. Preventive antifungal use in SOT needs to be re-examined in light of these current challenges. Cryptococcosis is the second most common IFI following SOT. Cryptococcus gattii is an emerging pathogen that can have reduced in-vitro susceptibility to antifungal agents. Cryptococcus associated IRIS in SOT is a clinical entity that warrants heightened awareness for timely recognition and management.
侵袭性念珠菌病(IC)仍然是实体器官移植(SOT)后最常见的侵袭性真菌感染,但风险因素正在发生变化。目前的挑战包括耐药性非白念珠菌和新型物种如耳念珠菌引起的感染。鉴于这些当前的挑战,需要重新审查 SOT 中预防性使用抗真菌药物的问题。隐球菌病是 SOT 后第二常见的 IFI。新型隐球菌是一种新兴的病原体,其对抗真菌药物的体外敏感性可能降低。SOT 中与隐球菌相关的 IRIS 是一种临床实体,需要提高认识,以便及时识别和管理。