Division of Infectious Diseases, Emory University School of Medicine, 101 Woodruff Circle, WMB #2101, Atlanta, GA 30322, USA.
Division of Infectious Diseases, Emory University School of Medicine, 101 Woodruff Circle, WMB #2101, Atlanta, GA 30322, USA.
Infect Dis Clin North Am. 2018 Sep;32(3):733-748. doi: 10.1016/j.idc.2018.05.001.
Clostridium difficile infection is a significant cause of morbidity and mortality in solid organ transplant recipients. Risk factors in this population include frequent hospitalizations, receipt of immunosuppressive agents, and intestinal dysbiosis triggered by several factors, including exposure to broad-spectrum antimicrobials. The incidence and potential for significant adverse outcomes among solid organ transplant recipients with C difficile infection highlight the evolving need for strategic C difficile infection risk factor modification and novel approaches to disease management in this patient population. This review focuses on current concepts related to the prevention and treatment of C difficile infection in solid organ transplant recipients.
艰难梭菌感染是实体器官移植受者发病率和死亡率的重要原因。该人群的危险因素包括频繁住院、接受免疫抑制剂治疗以及多种因素引发的肠道菌群失调，包括暴露于广谱抗生素。艰难梭菌感染的实体器官移植受者的发病率和潜在严重不良后果突出了在该患者人群中不断发展的对艰难梭菌感染危险因素修正和疾病管理新方法的战略需求。本综述重点介绍与实体器官移植受者艰难梭菌感染的预防和治疗相关的当前概念。
