Effect of dibutyryl cyclic adenosine monophosphate on canine pelviureteral discharge potentials.

An electromyographic study of the responses of the pelviureter to dibutyryl cyclic AMP was performed using isolated canine pelviureteral preparations. Dibutyryl cyclic AMP caused a marked increase in the amplitude of discharge potential in the pelvicalyceal pacemaker region and this was associated with a decrease in renal pelvic pressure. The frequency of the pacemaker discharge did not increase. On the other hand, in the lower pelvis and ureter, dibutyryl cyclic AMP caused a small but significant decrease in the amplitude of discharge potentials and this was associated with a marked decrease in discharge frequencies in the lower pelvis and ureter.