Departamento de Farmacologia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico (UNAM), Ciudad de Mexico, Mexico.
Unidad Periférica de Investigación en Biomedicina Traslacional, Facultad de Medicina, UNAM, Ciudad de México, México.
Curr Stem Cell Res Ther. 2019;14(5):389-397. doi: 10.2174/1574888X13666180821155701.
Cancer Stem Cells (CSCs) constitute a subpopulation at the top of the tumor cell hierarchy that contributes to tumor heterogeneity and is uniquely capable of seeding new tumors. Because of their biological properties, CSCs have been pointed out as therapeutic targets for the development of new therapies against breast cancer. The identification of drugs that selectively target breast CSCs requires a clear understanding of their biological functions and the experimental methods to evaluate such hallmarks. Herein, we review the methods to study breast CSCs properties and discuss their value in the preclinical evaluation of CSC-targeting drugs.
癌症干细胞（CSCs）构成了肿瘤细胞等级结构的顶端亚群，有助于肿瘤异质性，并且是唯一能够引发新肿瘤的细胞。由于其生物学特性，CSCs 已被指出是开发针对乳腺癌的新疗法的治疗靶点。鉴定选择性针对乳腺 CSCs 的药物需要清楚地了解其生物学功能以及评估这些特征的实验方法。本文综述了研究乳腺 CSCs 特性的方法，并讨论了它们在 CSC 靶向药物的临床前评估中的价值。
