Department of Medicine and Aging Sciences, University of Chieti-Pescara, Chieti, Italy.
Department of Hematology, Transfusion Medicine and Biotechnologies, Ospedale Civile, Pescara, Italy.
Front Immunol. 2018 Aug 10;9:1825. doi: 10.3389/fimmu.2018.01825. eCollection 2018.
In allogeneic hematopoietic stem cell transplantation, which is the major curative therapy for hematological malignancies, T cells play a key role in the development of graft-versus-host disease (GvHD). NOTCH pathway is a conserved signal transduction system that regulates T cell development and differentiation. The present review analyses the role of the NOTCH signaling as a new regulator of acute GvHD. NOTCH signaling could also represent a new therapeutic target for GvHD.
在异基因造血干细胞移植中，T 细胞在移植物抗宿主病（GvHD）的发展中起着关键作用，这是治疗血液系统恶性肿瘤的主要方法。NOTCH 通路是一种保守的信号转导系统，调节 T 细胞的发育和分化。本综述分析了 NOTCH 信号作为急性 GvHD 的新调节剂的作用。NOTCH 信号也可能成为 GvHD 的新治疗靶点。
