Pyaram Kalyani, Yadav Viveka Nand
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, USA.
Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, USA.
J Cancer Sci Ther. 2018;10(6). doi: 10.4172/1948-5956.1000533. Epub 2018 Jun 18.
Type I or invariant natural killer T cells belong to a unique lineage of innate T cells, which express markers of both T lymphocytes and NK cells, namely T cell receptor (TCR) and NK1.1 (CD161C), respectively. Thus, apart from direct killing of target cells like NK cells, and they also produce a myriad of cytokines which modulate the adaptive immune responses. Unlike traditional T cells which carry a conventional αβ TCR, NKT cells express semi-invariant TCR - Vα14-Jα18, coupled with Vβ8, Vβ7 and Vβ2 in mice. In humans, the invariant TCR is composed of Vα24-Jα18, coupled with Vβ11.
I型或不变自然杀伤T细胞属于先天T细胞的一个独特谱系，它们分别表达T淋巴细胞和NK细胞的标志物，即T细胞受体（TCR）和NK1.1（CD161C）。因此，除了像NK细胞那样直接杀伤靶细胞外，它们还产生大量调节适应性免疫反应的细胞因子。与携带传统αβ TCR的传统T细胞不同，NKT细胞表达半不变TCR——在小鼠中为Vα14-Jα18，与Vβ8、Vβ7和Vβ2偶联。在人类中，不变TCR由Vα24-Jα18组成，与Vβ11偶联。
