对感染艾滋病毒个体的代谢综合征评估。
Assessment of metabolic syndrome in HIV-infected individuals.
作者信息
Theengh Diki Palmu, Yadav Pushpa, Jain Amit Kumar, Nandy Parvati
机构信息
Department of General Medicine, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, India.
Department of General Medicine, PGIMER, Dr. Ram Manohar Lohia Hospital, New Delhi, India.
出版信息
Indian J Sex Transm Dis AIDS. 2017 Jul-Dec;38(2):152-156. doi: 10.4103/ijstd.IJSTD_55_16.
BACKGROUND
Metabolic syndrome (MS) is a cluster of risk factors for cardiovascular disease and Type 2 diabetes mellitus.
OBJECTIVES
The aim is to assess the prevalence of MS in HIV patients receiving highly active antiretroviral therapy (HAART) and to compare it with treatment naïve HIV patients.
METHODS
Cross-sectional study carried out in a teaching hospital in North India. A total of 116 HIV positive patients who were on HAART and those who were treatment naïve were included in the study. Adult Treatment Panel III (ATP III) and International Diabetes Foundation (IDF) definitions were used to define MS. Clinical and laboratory investigations were performed as per requirement and then analyzed using SPSS software.
RESULTS
A high prevalence of MS was observed in HIV positive patients (ATP III - 19.8% and IDF - 25.9%). The prevalence of MS was higher in the anti-retroviral therapy (ART) group (ATP III - 33.3% and IDF - 36.4%) than ART-naïve group (ATP III - 2% and IDF - 12%).
CONCLUSIONS
A sincere effort should always be made to detect MS in patients on HAART, especially in Indian subcontinent where there is a genetic predisposition to cardiovascular risk.
背景
代谢综合征（MS）是心血管疾病和2型糖尿病的一组危险因素。
目的
旨在评估接受高效抗逆转录病毒治疗（HAART）的HIV患者中MS的患病率，并将其与未接受治疗的HIV患者进行比较。
方法
在印度北部的一家教学医院开展横断面研究。共有116例接受HAART的HIV阳性患者和未接受治疗的患者纳入研究。采用成人治疗小组III（ATP III）和国际糖尿病联盟（IDF）的定义来界定MS。根据需要进行临床和实验室检查，然后使用SPSS软件进行分析。
结果
在HIV阳性患者中观察到MS的高患病率（ATP III - 19.8%，IDF - 25.9%）。抗逆转录病毒治疗（ART）组的MS患病率（ATP III - 33.3%，IDF - 36.4%）高于未接受ART治疗的组（ATP III - 2%，IDF - 12%）。
结论
对于接受HAART治疗的患者，尤其是在存在心血管疾病遗传易感性的印度次大陆，应始终切实努力检测MS。
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