Yang Michael C, Al-Hashimi Saba, Rootman Daniel B
a David Geffen School of Medicine, University of California , Los Angeles , CA , USA.
b Division of Cornea, External Ocular Disease & Refractive Surgery, Stein Eye Institute, University of California , Los Angeles , CA , USA.
Orbit. 2019 Aug;38(4):325-327. doi: 10.1080/01676830.2018.1505921. Epub 2018 Aug 27.
Salzmann's nodular degeneration (SND) typically occurs in patients who are female, 50-60 years old, and have a history of corneal inflammation and irritation. Multiple case reports have documented associations between SND and trachoma, viral infections, trauma, contact lens wear, corneal surgeries and corneal exposure. The authors describe a patient with bilateral SND confirmed by anterior segment optical coherence tomography (OCT) imaging in the context of thyroid eye disease (TED) and history of LASIK. Treatment involved propylthiouracil (PTU), artificial tear use, loteprednol etabonate ophthalmic gel, eyelid taping and selenium supplementation and prospective superficial keratectomy with diamond burr polish.
萨尔兹曼结节性变性（SND）通常发生于50至60岁的女性患者，且这些患者有角膜炎症和刺激史。多例病例报告记录了SND与沙眼、病毒感染、外伤、佩戴隐形眼镜、角膜手术及角膜暴露之间的关联。作者描述了一名双侧SND患者，该患者经眼前段光学相干断层扫描（OCT）成像确诊，其患有甲状腺眼病（TED）并有准分子激光原位角膜磨镶术（LASIK）史。治疗措施包括使用丙硫氧嘧啶（PTU）、人工泪液、氯替泼诺妥布霉素眼用凝胶、眼睑包扎及补充硒，以及采用钻石磨头抛光的前瞻性浅表角膜切除术。
