a Division of Infectious Diseases , Medical College of Wisconsin , Milwaukee , WI , USA.
Cancer Biol Ther. 2019;20(2):138-140. doi: 10.1080/15384047.2018.1508622. Epub 2018 Aug 27.
Chronic lymphocytic leukemia (CLL) is a disorder of B cells that affects humoral as well as cell-mediated immunity. Protection against cryptococcal infections is mounted by an intricate and synchronized interplay of both integral arms of immunity. Whether CLL or small molecule tyrosine kinase inhibitors are independently predisposing hosts to cryptococcal infections remain to be explored. Herein, we present a report of a patient who developed disseminated cryptococcosis while receiving ibrutinib therapy for CLL in the salvage setting. We further present relevant literature available thus far on the topic and discuss immunologic mechanisms that may be involved in the fungal pathogenesis in such patients.
慢性淋巴细胞白血病（CLL）是一种 B 细胞疾病，影响体液免疫和细胞免疫。对隐球菌感染的保护是由免疫的两个完整分支的复杂和同步相互作用产生的。CLL 或小分子酪氨酸激酶抑制剂是否会使宿主独立易患隐球菌感染仍有待探索。在此，我们报告了 1 例在挽救性治疗 CLL 时接受伊布替尼治疗的患者发生播散性隐球菌病的病例。我们进一步介绍了迄今为止关于该主题的相关文献，并讨论了可能涉及此类患者真菌感染发病机制的免疫机制。
