Caplow M
Ann N Y Acad Sci. 1986;466:510-8. doi: 10.1111/j.1749-6632.1986.tb38428.x.
The rate for GTP hydrolysis remains approximately constant during microtubule assembly from microtubular protein. This indicates that GTP hydrolysis does not accompany tubulin-GTP subunit addition to microtubule ends. We suggest that GTP, within tubulin-GTP subunits that are incorporated into microtubules, is hydrolyzed predominantly at one or both microtubule ends at an interface of a cap of tubulin-GTP subunits and a core of tubulin-GDP subunits.
在由微管蛋白组装微管的过程中，GTP水解的速率大致保持恒定。这表明GTP水解并不伴随微管蛋白-GTP亚基添加到微管末端。我们认为，掺入微管中的微管蛋白-GTP亚基内的GTP，主要在微管蛋白-GTP亚基帽与微管蛋白-GDP亚基核心的界面处的一个或两个微管末端水解。
