血清CK 18 - M30反映了大鼠非酒精性脂肪性肝病（NAFLD）进展过程中的肝脏病理严重程度。

Serum CK 18-M30 reflect liver pathological severity during NAFLD progression in a rat model.

作者信息

Xue Li, Lu Xiaolan, He Juntao, Zhang Ting, Wu Xiaokang, Zhang Yanping, Wang Ningning, An Zhe, Xu Jiru, Geng Yan

机构信息

Department of Laboratory, The Second Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China.

Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China.

出版信息

Pathol Res Pract. 2018 Nov;214(11):1778-1786. doi: 10.1016/j.prp.2018.08.016. Epub 2018 Aug 20.

DOI:10.1016/j.prp.2018.08.016

PMID:30149902

Abstract

BACKGROUND

CK 18-M30 was increased in patients with NAFLD. However, little is known about the relationship between CK 18-M30 and NAFLD progression. We aimed to analyze the variety of CK 18-M30 and other metabolism indices during NAFLD progression. Meanwhile, we aimed to investigate the correlation between CK 18-M30 and liver pathology during NAFLD progression.

MATERIALS AND METHODS

Rats were fed with high sucrose and high fat diet for building NAFLD models. We detected liver pathology by hematoxylin-eosin (HE) staining. We also detected serum CK 18-M30 and metabolism indices including liver enzymes, serum lipids and glycometabolism indices.

RESULTS

The aggravating degree of liver pathology appeared with prolonged feeding period. The relevance of CK 18-M30 to the severity of liver pathology were higher relative to other indices.

CONCLUSION

Our results suggested the significance of CK 18-M30 in the progression of NAFLD and provided new evidence for the early diagnosis and prognostic estimation of NAFLD.

摘要

背景

非酒精性脂肪性肝病（NAFLD）患者的细胞角蛋白18-M30（CK 18-M30）水平升高。然而，关于CK 18-M30与NAFLD进展之间的关系，人们知之甚少。我们旨在分析NAFLD进展过程中CK 18-M30及其他代谢指标的变化情况。同时，我们旨在研究NAFLD进展过程中CK 18-M30与肝脏病理学之间的相关性。