土耳其人群中冠状动脉疾病患者的内皮脂肪酶基因多态性（584 C/T）
Endothelial Lipase Gene Polymorphism (584 C/T) in Coronary Artery Patients Among a Turkish Population.
作者信息
Solim Levent Akman, Gencan Izgi Ayçil, Çelik Behiç, Ataacar Alara, Koç Umut, Büyükören Beyza, Güngör Gizem, Isbir Selim
机构信息
Faculty of Medicine, Yeditepe University, Istanbul, Turkey
Faculty of Medicine, Yeditepe University, Istanbul, Turkey.
出版信息
In Vivo. 2018 Sep-Oct;32(5):1105-1109. doi: 10.21873/invivo.11352.
BACKGROUND/AIM: The endothelial lipase gene (LIPG) has a major role in regulating high density lipoprotein cholesterol (HDL-C), therefore this study investigated whether LIPG is associated with coronary artery disease (CAD) in a Turkish population.
MATERIALS AND METHODS
The LIPG (584 C/T) mutation was analyzed in 74 CAD patients and 73 controls.
RESULTS
There was a significant difference between the two groups regarding the mutant T allele frequencies (χ=0.456, p=0.020; 26.7% and 41.8% in patient and control groups, respectively) for 584 C/T. Even though the TT genotype was not significantly different, it had p=0.054 which supported our results.
CONCLUSION
The endothelial lipase gene (584 C/T) T allele might be protective in association with coronary artery disease. Therefore, LIPG gene is related to risk for CAD in the Turkish population probably through altering HDL-C metabolism.
背景/目的：内皮脂肪酶基因（LIPG）在调节高密度脂蛋白胆固醇（HDL-C）方面起主要作用，因此本研究调查了LIPG是否与土耳其人群的冠状动脉疾病（CAD）相关。
材料与方法
分析了74例CAD患者和73例对照者的LIPG（584 C/T）突变情况。
结果
两组之间584 C/T的突变T等位基因频率存在显著差异（χ=0.456，p=0.020；患者组和对照组分别为26.7%和41.8%）。尽管TT基因型无显著差异，但其p=0.054，这支持了我们的结果。
结论
内皮脂肪酶基因（584 C/T）的T等位基因可能对冠状动脉疾病具有保护作用。因此，LIPG基因可能通过改变HDL-C代谢与土耳其人群的CAD风险相关。
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