维生素D3在胰腺癌介导的脂肪细胞/成纤维细胞转分化中的可能作用。
Possible role of vitamin D3 on the adipocyte/fibroblast trans-differentiation mediated by pancreas cancer.
作者信息
Chirumbolo S
机构信息
Laboratory of Physiopathology of Obesity, University Laboratory of Medical Research-Department of Medicine, University of Verona, Italy.
出版信息
Curr Health Sci J. 2015 Jan-Mar;41(1):5-10. doi: 10.12865/CHSJ.41.01.01. Epub 2015 Mar 15.
In pancreatic tumors, white adipose tissue and metabolic disorders related to adipocytes, are recently reviewed as important co-factors in pancreas pathology. Cell differentiation in pancreatic cancer might involve therefore adipose tissue and factors released by adipocytes should play a fundamental role both in cancer onset and in its progression. Among these molecules, a great interest has been devoted quite recently to the hormonal role exerted by vitamin D3 in pancreatic cancer, particularly its active 1,25 dihydroxylated form. Despite the wide bulk of evidence reporting the chemopreventive role of vitamin D, the mechanism by which active vitamin D3 is able to counteract cancer progression and malignancy is yet far to be elucidated.
在胰腺肿瘤中，白色脂肪组织以及与脂肪细胞相关的代谢紊乱，最近被视为胰腺病理学中的重要辅助因素。因此，胰腺癌中的细胞分化可能涉及脂肪组织，并且脂肪细胞释放的因子在癌症的发生和发展中都应发挥重要作用。在这些分子中，最近人们对维生素D3在胰腺癌中发挥的激素作用，尤其是其活性1,25二羟基化形式，产生了浓厚兴趣。尽管有大量证据表明维生素D具有化学预防作用，但活性维生素D3能够对抗癌症进展和恶性肿瘤的机制仍有待阐明。
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