Chirumbolo Salvatore, Bjørklund Geir
Department of Medicine, University of Verona, Italy.
Council for Nutritional and Environmental Medicine, Mo i Rana, Norway.
Eur J Cancer. 2016 Sep;64:96-100. doi: 10.1016/j.ejca.2016.05.026. Epub 2016 Jul 5.
Wnt5a has been recently reported as a possible triggering factor of adipocyte de-differentiation into an adipocyte-derived fibroblast in the tumour microenvironment of pancreas cancer. The Wnt/β-catenin pathway was described in processes involving de-differentiation and epithelial-mesenchymal transition but some Wnt family-belonging molecules exert an adipogenic role on adipocyte, while other ones, such as Wnt10b or Wnt3a, an anti-adipogenic role. Although this ability depends on the different tumoural microenvironments, it is intriguing to ascertain if some Wnt molecules, participating in the non-canonical pathway, may be targeted as fundamental factors able to trigger the desmoplastic reaction of peritumoural white adipose tissue.
最近有报道称，Wnt5a可能是胰腺癌肿瘤微环境中脂肪细胞去分化为脂肪来源成纤维细胞的触发因素。Wnt/β-连环蛋白通路在涉及去分化和上皮-间质转化的过程中被描述过，但一些属于Wnt家族的分子对脂肪细胞发挥促脂肪生成作用，而其他一些分子，如Wnt10b或Wnt3a，则发挥抗脂肪生成作用。尽管这种能力取决于不同的肿瘤微环境，但确定参与非经典通路的一些Wnt分子是否可能作为触发肿瘤周围白色脂肪组织促结缔组织增生反应的关键因素而成为靶点，这一点很有趣。
