Joshi D S, Deys B F, Kipp J B, Barendsen G W, Kralendonk J
Int J Radiat Biol Relat Stud Phys Chem Med. 1977 May;31(5):485-92. doi: 10.1080/09553007714550581.
Three types of cultured mammalian cells, from a rat ureter carcinoma (RUC-2), from a mouse mammary carcinoma (M8013), and from a Chinese hamster lung cell-line (CH-V79), have been compared with respect to various treatments. Using cloning assay, the sensitivity of these cell-lines was measured for ionizing radiation, U.V.-light and for temperatures of 41 degrees, 42 degrees, 43 degrees, 44 degrees and 45 degrees C. RUC-2 cells are the least sensitive to these treatments, except for 45 degrees C. M8013 is sensitive to gamma-rays and U.V.-irradiation. CH-V79 is sensitive to gamma-radiation and hyperthermia. Since sensitivity to one type of treatment does not correlate with similar susceptibility to the others, it is concluded that different mechanisms may be involved in inactivation by these treatments.
对三种培养的哺乳动物细胞进行了各种处理的比较，这三种细胞分别来自大鼠输尿管癌（RUC - 2）、小鼠乳腺癌（M8013）和中国仓鼠肺细胞系（CH - V79）。采用克隆试验，测定了这些细胞系对电离辐射、紫外线以及41℃、42℃、43℃、44℃和45℃温度的敏感性。RUC - 2细胞对这些处理最不敏感，但对45℃处理除外。M8013对γ射线和紫外线照射敏感。CH - V79对γ辐射和热疗敏感。由于对一种处理的敏感性与对其他处理的类似敏感性不相关，因此得出结论，这些处理导致细胞失活可能涉及不同的机制。
