Division of Genetics and Genomics, Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA.
Departments of Pediatrics and Neurology, Harvard Medical School, Boston, MA.
Eur J Neurosci. 2019 Apr;49(7):900-908. doi: 10.1111/ejn.14135. Epub 2018 Sep 17.
Ray Guillery had broad research interests that spanned cellular neuroanatomy, but was perhaps best known for his investigation of the connectivity and function of the thalamus, especially the visual pathways. His work on the genetics of abnormal vision in albino mammals served as an early paradigm for genetic approaches for studying brain connectivity of complex species in general, and remains of major relevance today. This work, especially on the Siamese cat, illustrates the complex relationship between genotype and physiology of cerebral cortical circuits, and anticipated many of the issues underlying the imperfect relationship between genes, circuits, and behavior in mammalian species including human. This review also briefly summarizes studies from our own lab inspired by Ray Guillery's legacy that continues to explore the relationship between genes, structure, and behavior in human cerebral cortex.
雷·圭利尔（Ray Guillery）的研究兴趣广泛，涵盖细胞神经解剖学，但他最为人所知的是对丘脑的连接和功能的研究，尤其是视觉通路。他在白化哺乳动物异常视觉的遗传学方面的工作为研究一般复杂物种的大脑连接的遗传方法提供了早期范例，并且今天仍然具有重要意义。这项工作，特别是关于暹罗猫的工作，说明了大脑皮层回路的基因型和生理学之间的复杂关系，并预测了包括人类在内的哺乳动物物种中基因、回路和行为之间这种不完善关系的许多问题。这篇综述还简要总结了我们实验室受雷·圭利尔的研究启发而进行的研究，这些研究继续探索人类大脑皮层中基因、结构和行为之间的关系。
