Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Eur J Neurosci. 2019 Apr;49(8):990-1004. doi: 10.1111/ejn.13979. Epub 2018 Aug 16.
Ray Guillery was a neuroscientist known primarily for his ground-breaking studies on the development of the visual pathways and subsequently on the nature of thalamocortical processing loops. The legacy of his work, however, extends well beyond the visual system. Thanks to Ray Guillery's pioneering anatomical studies, the ferret has become a widely used animal model for investigating the development and plasticity of sensory processing. This includes our own work on the auditory system, where experiments in ferrets have revealed the role of sensory experience during development in shaping the neural circuits responsible for sound localization, as well as the capacity of the mature brain to adapt to changes in inputs resulting from hearing loss. Our research has also built on Ray Guillery's ideas about the possible functions of the massive descending projections that link sensory areas of the cerebral cortex to the thalamus and other subcortical targets, by demonstrating a role for corticothalamic feedback in the perception of complex sounds and for corticollicular projection neurons in learning to accommodate altered auditory spatial cues. Finally, his insights into the organization and functions of transthalamic corticocortical connections have inspired a raft of research, including by our own laboratory, which has attempted to identify how information flows through the thalamus.
雷·圭利尔（Ray Guillery）是一位神经科学家，以其在视觉通路发育方面的开创性研究以及随后在丘脑皮质处理回路的性质方面的研究而闻名。然而，他的工作的影响远远超出了视觉系统。由于雷·圭利尔（Ray Guillery）的开创性解剖学研究，雪貂已成为广泛用于研究感觉处理的发育和可塑性的动物模型。这包括我们自己在听觉系统方面的工作，在雪貂中的实验揭示了在发育过程中感觉经验在塑造负责声音定位的神经回路中的作用，以及成熟大脑适应由于听力损失而导致的输入变化的能力。我们的研究还基于雷·圭利尔（Ray Guillery）关于将大脑皮质感觉区域与丘脑和其他皮质下靶区连接起来的大量下行投射可能具有的功能的想法，通过证明皮质丘脑反馈在复杂声音感知中的作用以及皮质丘状投射神经元在适应改变的听觉空间线索方面的作用，建立了联系。最后，他对丘脑间皮质皮质连接的组织和功能的深入了解激发了大量研究，包括我们自己的实验室，该实验室试图确定信息如何通过丘脑流动。
