Department of Pediatric Oncology, Emma Children's Hospital Academic Medical Center, Amsterdam, The Netherlands.
Pediatric Psychosocial Department, Emma Children's Hospital Academic Medical Center, Amsterdam, The Netherlands.
Pediatr Blood Cancer. 2019 Jan;66(1):e27419. doi: 10.1002/pbc.27419. Epub 2018 Aug 27.
Adaptive behavior, i.e., the performance on daily activities required for personal and social independence, is essential to estimate in children with low-grade glioma (LGG) since most of them are long-term survivors. Our aim was to investigate adaptive behavior in children with LGG.
In a cross-sectional study, adaptive behavior was assessed using the paper pencil version of the Parent Form of the Vineland Adaptive Behavior Scales 2nd edition (VABS-II) testing communication, daily living skills, social skills, and motor skills. Scores of children with LGG, younger than 20 years, and diagnosed between 2004 and 2014 were compared with family controls. Correlations between clinical variables and adaptive behavior were explored.
Fifty-six children with LGG (median age, 12.1 years; 52% male) and 46 controls (median age, 11.0 years; 43% male) were included in the analyses. Compared with controls, the LGG group was more impaired on total adaptive behavior, communication, and motor skills and in the subdomain gross motor skills (effect sizes d, 0.64-0.86, P < 0.003). Younger age at diagnosis (r = -0.357, P < 0.01) and chemotherapy (r = -0.342, P < 0.05) were associated with poorer motor skills. Residual disease was associated with poorer total adaptive behavior (r = -0.282, P < 0.05). No other significant correlations were found.
At the group level, adaptive functioning of children with LGG is impaired compared with family controls. Regular structured monitoring of adaptive behavior is recommended to be able to define the needs for tailored rehabilitation in daily life at home as well as at school.
适应行为，即个人和社会独立所需的日常活动表现，对于评估低级别胶质瘤 (LGG) 患儿至关重要，因为他们大多数都是长期幸存者。我们的目的是研究 LGG 患儿的适应行为。
在一项横断面研究中，使用维兰纳适应行为量表第二版（VABS-II）的纸质铅笔家长形式评估适应行为，测试沟通、日常生活技能、社会技能和运动技能。将 2004 年至 2014 年间诊断为 LGG 且年龄小于 20 岁的患儿与家庭对照进行比较。探讨临床变量与适应行为之间的相关性。
56 名 LGG 患儿（中位年龄 12.1 岁，52%为男性）和 46 名对照（中位年龄 11.0 岁，43%为男性）纳入分析。与对照组相比，LGG 组在总适应行为、沟通和运动技能以及大运动技能子领域方面受损更严重（效应大小 d，0.64-0.86，P<0.003）。诊断时年龄较小（r=-0.357，P<0.01）和化疗（r=-0.342，P<0.05）与运动技能较差相关。残留疾病与总适应行为较差相关（r=-0.282，P<0.05）。未发现其他显著相关性。
在组水平上，与家庭对照组相比，LGG 患儿的适应功能受损。建议定期进行结构化的适应行为监测，以便能够确定在家庭和学校日常生活中需要进行个性化康复的需求。
