基于N,N,N,N-四甲基乙二胺的新型离子液体的合成、表征及其在1,8-二氧代八氢呫吨合成中的应用
Synthesis and Characterization of a Novel Ionic Liquid Based on N,N,N,N-tetramethylethylenediamine and its Application in the Synthesis of 1,8-dioxo-octahydro Xanthenes.
作者信息
Piralghar Zahra Abdi, Hashemi Mohammad Mahmoodi, Ezabadi Ali
机构信息
Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Department of Chemistry, Faculty of Science, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
出版信息
Comb Chem High Throughput Screen. 2018;21(7):526-532. doi: 10.2174/1386207321666180828092546.
AIM AND OBJECTIVE
In this work, we synthesized and characterized a novel Brönsted acidic ionic liquid from the reaction of N, N, N', N'-tetramethylethylenediamine with chlorosulfonic acid and explored its catalytic activity in 1, 8-dioxo-octahydroxanthenes synthesis.
MATERIALS AND METHODS
Dimedone, aryl aldehydes, and the ionic liquid as the catalyst were reacted under solvent-free conditions. The progressive of the reaction was monitored by a thin layer of chromatography (ethyl acetate/n-hexane = 1/5). All products were characterized as the basis of their spectra data and melting point by comparison with those reported in the literature.
RESULTS
The prepared ionic liquid was successfully applied in the synthesis of 1, 8-dioxooctahydroxanthenes in good to high yields on the reaction of aryl aldehyde and dimedone at 120°C under solvent-free conditions.
CONCLUSION
This research demonstrates that the catalyst is impressive for 1, 8-dioxo-octahydroxanthenes synthesis under solvent-free conditions.
目的与目标
在本研究中，我们通过N，N，N'，N'-四甲基乙二胺与氯磺酸反应合成并表征了一种新型布朗斯特酸性离子液体，并探索了其在1,8 - 二氧代八氢占吨合成中的催化活性。
材料与方法
将二甲基环己二酮、芳醛和作为催化剂的离子液体在无溶剂条件下反应。通过薄层色谱法（乙酸乙酯/正己烷 = 1/5）监测反应进程。通过与文献报道的数据比较，根据所有产物的光谱数据和熔点对其进行表征。
结果
在无溶剂条件下，于120°C使芳醛与二甲基环己二酮反应，所制备的离子液体成功应用于1,8 - 二氧代八氢占吨的合成，产率良好至高。
结论
本研究表明，该催化剂在无溶剂条件下用于1,8 - 二氧代八氢占吨的合成效果显著。
Zotero 插件