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南非私立医疗保健机构中稳定型心绞痛的管理

Management of stable angina pectoris in private healthcare settings in South Africa.

作者信息

Tlhakudi Pride, Mathibe Lehlohonolo John

机构信息

Division of Pharmacology (Therapeutics), University of KwaZulu-Natal, Durban, South Africa.

Division of Pharmacology (Therapeutics), University of KwaZulu-Natal, Durban, South Africa. Email:

出版信息

Cardiovasc J Afr. 2018;29(4):237-240. doi: 10.5830/CVJA-2018-020. Epub 2018 Aug 10.

Abstract

AIM

Angina pectoris continues to affect multitudes of people around the world. In this study the management of stable angina pectoris in private healthcare settings in South Africa (SA) was investigated. In particular, we reviewed the frequency of medical versus surgical interventions when used as first-line therapy.

METHODS

This was a retrospective inferential study carried out using records of patients in private healthcare settings. All cases that were authorised for reimbursement by medical aid schemes for revascularisation between 2009 and 2014 were retrieved and a database was created. Data were analysed using Microsoft Excel and GraphPad Prism version 5. The differences (where applicable) were considered statistically significant if the -value was ≤ 0.05.

RESULTS

Nine hundred and twenty-two patients, consisting of 585 males (average age 64.7 years; SD 12.9) and 337 females (average age 65.5 years; SD 14.3), met the inclusion criteria. One hundred and seventy-eighty or 54%, 156 (43%) and 86 (63%) patients with hypertension, hyperlipidaemia and diabetes, respectively, were treated with surgery only. For these patients, percutaneous coronary interventions (PCIs) were significantly ( < 0.0001) preferred first-line interventions over optimal medical therapy (OMT). Four hundred and thirty-six or 47% of all patients studied were managed with surgery only, while only 25% (227) were managed with OMT. It took 60 months (five years) for patients who were treated with OMT before their first surgical intervention(s) to require the second revascularisation. About 71% of patients who received medical therapy were placed on only one drug, the so called sub-optimal medical therapy (SOMT).

CONCLUSIONS

The management of stable angina pectoris in private healthcare settings in SA is skewed towards surgical interventions as opposed to OMT. This is contrary to what consistent scientific evidence and international treatment guidelines suggest.

摘要

目的

心绞痛持续影响着世界各地众多人群。本研究对南非私立医疗机构中稳定型心绞痛的治疗情况进行了调查。具体而言,我们回顾了作为一线治疗手段时,药物治疗与手术干预的使用频率。

方法

这是一项回顾性推断研究,利用私立医疗机构患者的记录开展。检索了2009年至2014年间经医疗救助计划批准报销血运重建费用的所有病例,并创建了一个数据库。使用Microsoft Excel和GraphPad Prism 5版本进行数据分析。如果P值≤0.05,则(适用时)差异被认为具有统计学意义。

结果

922名患者符合纳入标准,其中男性585名(平均年龄64.7岁;标准差12.9),女性337名(平均年龄65.5岁;标准差14.3)。分别有178名(54%)、156名(43%)和86名(63%)患有高血压、高脂血症和糖尿病的患者仅接受了手术治疗。对于这些患者,经皮冠状动脉介入治疗(PCI)作为一线干预措施明显(P<0.0001)优于最佳药物治疗(OMT)。在所有研究患者中,436名(47%)仅接受了手术治疗,而只有25%(227名)接受了OMT治疗。接受OMT治疗的患者在首次手术干预前需要60个月(五年)才需要进行第二次血运重建。接受药物治疗的患者中约71%仅使用一种药物,即所谓的次优药物治疗(SOMT)。

结论

南非私立医疗机构中稳定型心绞痛的治疗倾向于手术干预而非OMT。这与一致的科学证据和国际治疗指南所建议的情况相反。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59fa/6421554/85bf8a3ec50f/cvja-29-239-g001.jpg

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