Nabeshima T, Hiramatsu M, Kameyama T
Brain Res. 1986 Jul 23;378(2):234-9. doi: 10.1016/0006-8993(86)90926-1.
The effects of ethylketocyclazocine (EKC), Mr 2266 and naltrexone on the stereotyped behaviors induced by an intraperitoneal injection of phencyclidine (PCP) were examined. PCP-induced turning, backpedalling, head weaving and sniffing were antagonized by pretreatment with EKC (0.25-4.0 mg/kg). While pretreatment with Mr 2266 (2.5 mg/kg), a kappa selective antagonist, and naltrexone (10 mg/kg), a mu selective antagonist, failed to affect the PCP-induced stereotypy, Mr 2266 antagonized the suppressing effect of EKC on PCP-induced stereotypy. Taken into consideration, this suggests that kappa opioid agonists such as EKC antagonize PCP-induced stereotyped behaviors through a kappa opioid mechanism, and that the mu opioid receptor may not play an important role in the PCP-induced stereotypy in rats.
研究了乙基酮环唑辛（EKC）、Mr 2266和纳曲酮对腹腔注射苯环己哌啶（PCP）诱导的刻板行为的影响。EKC（0.25 - 4.0毫克/千克）预处理可拮抗PCP诱导的旋转、倒退、头部摆动和嗅探行为。虽然κ选择性拮抗剂Mr 2266（2.5毫克/千克）和μ选择性拮抗剂纳曲酮（10毫克/千克）预处理未能影响PCP诱导的刻板行为，但Mr 2266拮抗了EKC对PCP诱导的刻板行为的抑制作用。综合考虑，这表明EKC等κ阿片类激动剂通过κ阿片类机制拮抗PCP诱导的刻板行为，并且μ阿片受体可能在大鼠PCP诱导的刻板行为中不起重要作用。
