下丘脑腹内侧核中脑啡肽能神经纤维向葡萄糖受体神经元投射的超微结构证据。

Ultrastructural evidence of enkephalinergic input to glucoreceptor neurons in ventromedial hypothalamic nucleus.

作者信息

Inagaki S, Kubota Y, Kito S, Fukuda M, Ono T, Yamano M, Tohyama M

出版信息

Brain Res. 1986 Jul 23;378(2):420-4. doi: 10.1016/0006-8993(86)90949-2.

Abstract

A combination of intracellular injection of horseradish peroxidase into the ventromedial hypothalamic nucleus glucoreceptor neurons and immunohistochemical staining for enkephalin allowed ultrastructural visualization of interrelations between these electrophysiologically identified neurons and enkephalin-like immunoreactive (ENK-IR) terminals. The results show that glucoreceptor neurons receive direct inputs from ENK-IR neurons. This is the first evidence that glucoreceptor neurons, identified electrophysiologically, can be affected monosynaptically by endogenous enkephalin, probably released from ENK-IR terminals.

摘要

将辣根过氧化物酶细胞内注射到腹内侧下丘脑核葡萄糖受体神经元中，并对脑啡肽进行免疫组织化学染色，这样可以在超微结构水平观察这些经电生理学鉴定的神经元与脑啡肽样免疫反应（ENK-IR）终末之间的相互关系。结果表明，葡萄糖受体神经元接受来自ENK-IR神经元的直接输入。这是首个证据，表明经电生理学鉴定的葡萄糖受体神经元可受到内源性脑啡肽的单突触影响，而内源性脑啡肽可能是从ENK-IR终末释放的。