Department of Physics & I3N, University of Aveiro, Aveiro, Portugal.
Instituto de Telecomunicações, Aveiro, Portugal.
Hypertens Res. 2018 Nov;41(11):904-912. doi: 10.1038/s41440-018-0089-2. Epub 2018 Aug 28.
The aim of this study, enrolling 118 patients, was to clinically evaluate the accuracy of carotid pulse waveform acquisition with a new non-invasive optical fiber probe using invasive and non-invasive pressure readings as references. Pulse waves were acquired simultaneously in the ascending aorta and right common carotid; for the non-invasive study, the pulses were sequentially acquired using the optical fiber device and the Complior Analyse (Alam Medical, France) device in the right carotid artery. For all subjects, the pulse waveforms assessed using the optical fiber sensor and the references were superimposed to analyze the deviation and point-by-point correlation. Augmentation index and central pressure were compared using intraclass correlation and Bland-Altman analyses with a confidence interval of 95%. For the invasive study, the acquired waves presented a mean deviation of 11 ± 3% and a mean intraclass correlation of 0.97 ± 0.02. Concerning the augmentation index and central systolic pressure, correlations of 0.79 (p < 0.001) and 0.94 (p < 0.001) were found, respectively. In the non-invasive comparison, the assessed mean deviation between the morphologies of the waves was 13 ± 5%, with correlation coefficients of 0.91 (p < 0.001) for the augmentation index and 0.98 (p < 0.001) for central systolic pressure. The results show that the optical fiber probe results were highly correlated with those obtained using the reference techniques in terms of the pulse waveforms, central systolic pressure (cSP), and augmentation index assessment.
本研究纳入了 118 名患者，旨在临床评估使用新型无创光纤探头获取颈动脉脉搏波的准确性，该探头以有创和无创血压读数为参考。脉搏波在升主动脉和右颈总动脉同时采集；在无创研究中，使用光纤设备和 Complior Analyse（法国 Alam Medical）设备依次在右颈动脉采集脉搏。对于所有受试者，使用光纤传感器和参考值评估的脉搏波进行叠加，以分析偏差和逐点相关性。使用组内相关和 Bland-Altman 分析比较了增强指数和中心血压，置信区间为 95%。对于有创研究，获得的波呈现出 11±3%的平均偏差和 0.97±0.02 的平均组内相关。关于增强指数和中心收缩压，分别发现了 0.79（p<0.001）和 0.94（p<0.001）的相关性。在非侵入性比较中，评估的波形态之间的平均偏差为 13±5%，增强指数的相关系数为 0.91（p<0.001），中心收缩压的相关系数为 0.98（p<0.001）。结果表明，光纤探头的结果与参考技术在脉搏波、中心收缩压（cSP）和增强指数评估方面具有高度相关性。
