MacLean A B, Lynn K L, Bailey R R, Swainson C P, Walker R J
Clin Nephrol. 1986 Jul;26(1):45-7.
The incidence of epithelial or cutaneous abnormality of the lower genital tract was studied colposcopically in 31 women aged 35 (SD9) years on renal replacement therapy for one to 184 months (mean 73 months). Twenty-four women had a renal transplant and had received immunosuppressive therapy for two to 173 months (mean 61 months). Seven women (two with failed transplants) were on home hemodialysis (one to 48 months, mean 19 months) awaiting transplantation. In 22 women (17 transplant and 5 dialysis patients) no abnormality was found. One hemodialysis patient had an extensive area of vulval intra-epithelial neoplasia. Five transplant recipients had evidence of genital papilloma virus (HPV) infection. No patient had cervical intra-epithelial neoplasia or invasive genital tract malignancy. The high incidence of HPV-associated lesions in this group, and the increasing evidence that HPV changes may predispose to cervical neoplasia suggest that this high risk group require regular gynecological assessment.
对31名年龄为35（标准差9）岁、接受肾脏替代治疗1至184个月（平均73个月）的女性进行了阴道镜检查，以研究下生殖道上皮或皮肤异常的发生率。24名女性接受了肾移植，并接受了2至173个月（平均61个月）的免疫抑制治疗。7名女性（2名移植失败）在家中进行血液透析（1至48个月，平均19个月），等待移植。22名女性（17名移植患者和5名透析患者）未发现异常。一名血液透析患者有大面积的外阴上皮内瘤变。5名移植受者有生殖器乳头瘤病毒（HPV）感染的证据。没有患者患有宫颈上皮内瘤变或侵袭性生殖道恶性肿瘤。该组中HPV相关病变的高发生率，以及越来越多的证据表明HPV变化可能易患宫颈癌，表明这一高危人群需要定期进行妇科评估。
