Sakata S, Ueda J, Hirata M
Chemotherapy. 1986;32(4):374-8. doi: 10.1159/000238437.
The effect of several antibiotics on rat platelet membrane fluidity was examined by ESR spectrometry using 5-doxyl stearate as the spin probe. Latamoxef, cefamandole, cefotaxime and carbenicillin had negligible effects on the order parameters, the indices of membrane fluidity, of platelet-rich plasma or washed platelets at high concentrations that would inhibit ADP-induced rat platelet aggregation in vitro. A further in vivo study with one of these antibiotics, latamoxef, showed no significant effect on the fluidity based on ESR data.
使用5-硬脂酰氧基氮氧自由基作为自旋探针，通过电子自旋共振光谱法检测了几种抗生素对大鼠血小板膜流动性的影响。拉氧头孢、头孢孟多、头孢噻肟和羧苄青霉素在高浓度下对富含血小板血浆或洗涤血小板的序参数（膜流动性指标）影响可忽略不计，这些高浓度药物在体外可抑制ADP诱导的大鼠血小板聚集。对其中一种抗生素拉氧头孢进行的进一步体内研究表明，基于电子自旋共振数据，其对膜流动性无显著影响。
