Ding J A
Zhonghua Zhong Liu Za Zhi. 1986 Jan;8(1):67-9.
Sixty patients with primary lung cancer and under 40 years of age were operated from Jan. 1960 to June 1983. It comprised 3.7% of 1,635 lung cancers in all during the same period. The average age was 34.4 (17-39) years old. 35 were male and 25 female with a sex ratio of 1.4:1 which was lower than that reported for all lung cancers. Of the 60 patients, 31 (51.7%) presented with cough, 27 (45%) with bloody sputum, 23 (43.3%) chest pain and 13 (21.7%) feverishness. The average delay before the first medical examination was 6.4 months. It was over 1 year in 8 patients. The misdiagnosis rate was 76.7%. According to the TNM classification, the lesions were: stage I in 16.7%, stage II in 23.3% and stage III in 60%. By pathology, 45% were adenocarcinoma, 25% squamous cell carcinoma, 23.3% undifferentiated carcinoma and 6.7% squamous-adenocarcinoma. The resection rate was 83.3% (50 patients). The 1, 3, 5, 7 and 10 year survival rates were 83.3%, 42.5%, 32.3%, 18.5% and 21.1% which show that the survival rate of lung cancer in the young adults was similar to that of all ages. Most of the patients treated only by exploration died within 1.5 years. The authors believe that early diagnosis, early resection supplemented by radiotherapy, chemotherapy and immunotherapy might improve the survival rate of lung cancer in the young adults.
1960年1月至1983年6月期间，60例年龄在40岁以下的原发性肺癌患者接受了手术治疗。这占同期1635例肺癌患者的3.7%。平均年龄为34.4岁（17 - 39岁）。男性35例，女性25例，性别比为1.4:1，低于所有肺癌报告的性别比。60例患者中，31例（51.7%）有咳嗽症状，27例（45%）有咯血，23例（43.3%）有胸痛，13例（21.7%）有发热。首次就医前的平均延误时间为6.4个月。8例患者超过1年。误诊率为76.7%。根据TNM分类，病变情况为：I期占16.7%，II期占23.3%，III期占60%。病理检查显示，45%为腺癌，25%为鳞状细胞癌，23.3%为未分化癌，6.7%为腺鳞癌。切除率为83.3%（50例）。1年、3年、5年、7年和10年生存率分别为83.3%、42.5%、32.3%、18.5%和21.1%，这表明青年肺癌患者的生存率与各年龄段肺癌患者相似。大多数仅接受探查治疗的患者在1.5年内死亡。作者认为，早期诊断、早期切除并辅以放疗、化疗和免疫治疗可能提高青年肺癌患者的生存率。
