大鼠心房利钠因子刺激肾皮质切片释放肾素。

Rat atrial natriuretic factor stimulates renin release from renal cortical slices.

作者信息

Hiruma M, Ikemoto F, Yamamoto K

出版信息

Eur J Pharmacol. 1986 Jun 5;125(1):151-3. doi: 10.1016/0014-2999(86)90095-6.

Abstract

We investigated the effect of synthetic rat atrial natriuretic factor (ANF) on renin release from rat renal cortical slices. Rat ANF (10(-6) M) increased renin release from the slices with a concomitant increase in the levels of cGMP contents. The increase in cGMP was also prominent in the case of incubation with 10(-4) M sodium nitroprusside but was not accompanied by an enhanced release renin. 8-Bromo-cGMP did not stimulate renin release. We propose that the stimulation of renin release from rat renal cortical slices is not related to an increase in endogenous cGMP.

摘要

我们研究了合成的大鼠心房利钠因子（ANF）对大鼠肾皮质切片肾素释放的影响。大鼠ANF（10⁻⁶ M）可增加切片中肾素的释放，同时cGMP含量水平也随之升高。在与10⁻⁴ M硝普钠共同孵育的情况下，cGMP的增加也很显著，但并未伴随肾素释放的增强。8-溴-cGMP不会刺激肾素释放。我们认为，大鼠肾皮质切片中肾素释放的刺激与内源性cGMP的增加无关。