Cheng Cheng, Dong Zhi-Long, Wang Zhi-Ping
Research Institute of Urology / Key Laboratory of Gansu Province for Urological Diseases / Clinical Center of Gansu Province for Urological Diseases, Lanzhou University Second Hospital, Lanzhou, Gansu 730030, China.
Zhonghua Nan Ke Xue. 2018;24(1):78-81.
The prevalence of erectile dysfunction (ED) is increasing, especially among men over 40 years old, and is positively correlated with age. It is predicted that there will be as many as 300 million ED patients around the world by the year 2025. Recent years has witnessed deeper insights into the pathophysiological mechanisms of ED and significant breakthroughs in its treatment. However, few achievements have been made in the studies of its pathological change at the molecular level and the measures for its management and rehabilitation. Besides, quite a few cases fail to respond to 5-phosphodiesterase inhibitors. Fortunately, low-intensity shock wave therapy (LiSWT), as a novel non-invasive micro-energy therapeutic option, is promising to get repaired the injured corpus cavernosum of the ED patient and provide a new concept for the management of ED. This review introduces the current situation of the diagnosis and treatment of ED and the mechanisms of LiSWT acting on ED in animal experiments and clinical studies.
勃起功能障碍（ED）的患病率正在上升，尤其是在40岁以上的男性中，并且与年龄呈正相关。预计到2025年，全球将有多达3亿ED患者。近年来，人们对ED的病理生理机制有了更深入的了解，其治疗也取得了重大突破。然而，在其分子水平的病理变化研究以及管理和康复措施方面却鲜有成果。此外，相当一部分病例对5-磷酸二酯酶抑制剂没有反应。幸运的是，低强度冲击波疗法（LiSWT）作为一种新型的非侵入性微能量治疗选择，有望修复ED患者受损的海绵体，并为ED的管理提供新的概念。本文综述了ED的诊断和治疗现状以及LiSWT在动物实验和临床研究中作用于ED的机制。
