单中心三级新生儿重症监护病房中孕周小于32周的婴儿的结局——与喂养策略的关系
Outcome of infants born at < 32 weeks' gestation in a single-centre level III neonatology unit - relation to feeding strategy.
作者信息
Kiechl-Kohlendorfer Ursula, Biermayr Marlene, Pupp Peglow Ulrike, Griesmaier Elke
机构信息
Department of Paediatrics II, Division of Neonatology, Medical University of Innsbruck, Innsbruck, Austria.
出版信息
J Int Med Res. 2018 Dec;46(12):5107-5116. doi: 10.1177/0300060518790706. Epub 2018 Aug 29.
OBJECTIVE
This study aimed to determine survival, neonatal morbidity, and outcomes at 1 and 2 years in children who were born very preterm, and to analyse any relation to enteral feeding.
METHODS
We performed a prospective, observational study on very preterm infants (range: 23-31 weeks' gestation) born at Innsbruck Medical University Hospital, Austria, between 2007 and 2014 (n = 557).
RESULTS
The overall survival rate was 94.6%. Survival rates were 77.8%, 78.6%, 90.9%, and 90.9% among those born at 24, 25, 26, and 27 weeks, and 97.3%, 95.3%, 98.3%, and 100% among those born at 28, 29, 30, and 31 weeks of gestation, respectively. The overall prevalence of chronic lung disease among survivors was 7.3%. The prevalence of necrotizing enterocolitis requiring surgery, intraventricular haemorrhage grades 3 and 4, and severe retinopathy of prematurity was 3.1%, 2.1%, and 6.2%, respectively. There was no difference in short-term morbidity or neurodevelopmental outcome at 1 or 2 years of corrected age between infants who were fed with human milk at discharge and those who were formula-fed.
CONCLUSION
In the current study, mortality and short-term morbidity rates were low. No differences regarding feeding strategy were detected.
目的
本研究旨在确定极早产儿1岁和2岁时的生存率、新生儿发病率及转归，并分析其与肠内喂养的关系。
方法
我们对2007年至2014年在奥地利因斯布鲁克医科大学医院出生的极早产儿（孕周范围：23 - 31周）进行了一项前瞻性观察研究（n = 557）。
结果
总体生存率为94.6%。孕24、25、26和27周出生者的生存率分别为77.8%、78.6%、90.9%和90.9%，孕28、29、30和31周出生者的生存率分别为97.3%、95.3%、98.3%和100%。幸存者中慢性肺病的总体患病率为7.3%。需要手术的坏死性小肠结肠炎、3级和4级脑室内出血以及严重早产儿视网膜病变的患病率分别为3.1%、2.1%和6.2%。出院时接受母乳喂养的婴儿与配方奶喂养的婴儿在矫正年龄1岁或2岁时的短期发病率或神经发育转归方面没有差异。
结论
在本研究中，死亡率和短期发病率较低。未检测到喂养策略方面的差异。
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