两种表型不同的T细胞（Ly1+2-和Ly1-2+）参与了紫外线B光诱导的体内对单纯疱疹病毒1型传出迟发型超敏反应的抑制。

Two phenotypically distinct T cells (Ly1+2- and Ly1-2+) are involved in ultraviolet-B light-induced suppression of the efferent DTH response to HSV-1 in vivo.

作者信息

Howie S E, Norval M, Maingay J, Ross J A

出版信息

Immunology. 1986 Aug;58(4):653-8.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1453103/

Abstract

We have previously demonstrated that the delayed-type hypersensitivity (DTH) response to herpes simplex virus type 1 induced by subcutaneous injection with live virus was suppressed by irradiating mice with a low dose (96 mJ/cm2) of ultraviolet-B (UV-B) light 3 days before sensitization. In order to determine the nature of the suppression, cells from mice irradiated with UV-B before immunization with live virus were transferred to syngeneic animals that had been sensitized with live virus without prior UV-B exposure. Efferent suppression of DTH to HSV-1 was shown to be due to T lymphocytes, and two phenotypically distinct T cells were involved: an Ly1+2- subset and an Ly1-2+ subset.

摘要

我们之前已经证明，在致敏前3天用低剂量（96 mJ/cm2）的紫外线B（UV-B）照射小鼠，可抑制皮下注射活病毒诱导的对1型单纯疱疹病毒的迟发型超敏反应（DTH）。为了确定抑制的性质，将在用活病毒免疫前用UV-B照射的小鼠的细胞转移到已用活病毒致敏但未事先暴露于UV-B的同基因动物中。对HSV-1的DTH传出抑制被证明是由于T淋巴细胞，并且涉及两种表型不同的T细胞：Ly1+2-亚群和Ly1-2+亚群。

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引用本文的文献

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本文引用的文献

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Systemic suppression of contact hypersensitivity by UVB radiation is unrelated to the UVB-induced alterations in the morphology and number of Langerhans cells.紫外线B辐射对接触性超敏反应的全身抑制作用与紫外线B诱导的朗格汉斯细胞形态和数量的改变无关。

Immunology. 1984 Jun;52(2):299-306.

2

Tolerance and suppression of immunity to herpes simplex virus: different presentations of antigens induce different types of suppressor cells.对单纯疱疹病毒免疫的耐受性与抑制作用：不同的抗原呈递诱导不同类型的抑制细胞。

Infect Immun. 1983 May;40(2):514-22. doi: 10.1128/iai.40.2.514-522.1983.

3

Cell-mediated immunity in herpes simplex virus-infected mice: H-2 mapping of the delayed-type hypersensitivity response and the antiviral T cell response.单纯疱疹病毒感染小鼠的细胞介导免疫：迟发型超敏反应和抗病毒T细胞反应的H-2定位

J Immunol. 1981 Apr;126(4):1260-2.

4

Cell-mediated immunity in herpes simplex virus-infected mice: induction, characterization and antiviral effects of delayed type hypersensitivity.单纯疱疹病毒感染小鼠的细胞介导免疫：迟发型超敏反应的诱导、特征及抗病毒作用

J Gen Virol. 1980 Jun;48(Pt 2):351-7. doi: 10.1099/0022-1317-48-2-351.

5

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J Immunol. 1984 May;132(5):2408-16.

6

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Cell Immunol. 1983 Feb 1;75(2):348-55. doi: 10.1016/0008-8749(83)90332-5.

7

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J Immunol. 1983 Mar;130(3):1413-8.

8

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Eur J Immunol. 1973 Oct;3(10):645-9. doi: 10.1002/eji.1830031011.

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