[A Case of Advanced Lung Squamous Cell Carcinoma with Idiopathic Pulmonary Fibrosis Treated with Salvage Surgery and Chemotherapy Using Carboplatin plus Nanoparticle Albumin-Bound Paclitaxel].

We present a case of a 74-year-old man who was a heavy smoker with a performance status of 0(Brinkman indexof 2080). In 2008, he was diagnosed with idiopathic pulmonary fibrosis and was treated with pirfenidone. During follow-up, abnormal chest shadows were observed. In May 2014, he was diagnosed with right middle lobe primary squamous cell carcinoma of the lung(C-T2aN2M1a, contralateral lung metastasis)IV a, for which chemotherapy was immediately initiated. After 3 courses of carboplatin(5 AUC, day 1)plus nanoparticle albumin-bound paclitaxel(100mg/m2, days 1, 8, and 15) treatment, the primary tumor markedly decreased in size(reduction ratio, 93.3%). Moreover, both the mediastinal lymph nodes and lung metastatic lesions disappeared, and the level of tumor marker CYFRA had decreased from 29.5 to 3.4 ng/mL. The patient then underwent thoracoscopic partial resection of the right middle lobe of the lung, as a combination of these chemotherapeutic agents with salvage surgery is the standard treatment regimen for residual middle lobe lung tumors. Subsequently, he was discharged from the hospital without complications. Three courses of the same chemotherapeutic agents were administered post-surgery. As of August 2017, the patient was alive without any recurrence during the outpatient follow-up.