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内镜下病灶内注射曲安奈德治疗良性食管狭窄的疗效与安全性

Efficacy and Safety of Endoscopic Intralesional Triamcinolone Injection for Benign Esophageal Strictures.

作者信息

Zhang Ya-Wu, Wei Feng-Xian, Qi Xue-Ping, Liu Zhao, Xu Xiao-Dong, Zhang You-Cheng

机构信息

Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730000, China.

Hepato-Biliary-Pancreatic Institute, Lanzhou University Second Hospital, Lanzhou 730000, China.

出版信息

Gastroenterol Res Pract. 2018 Aug 6;2018:7619298. doi: 10.1155/2018/7619298. eCollection 2018.

DOI:10.1155/2018/7619298
PMID:30158968
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6109539/
Abstract

OBJECTIVES

To evaluate the efficacy and safety of endoscopic intralesional triamcinolone injection (ITI) for benign esophageal strictures combined with endoscopic dilation (ED).

METHODS

Online databases including MEDLINE, EMBASE, the Cochrane Library, and Web of Science were comprehensively searched for prospective randomized control trials (RCTs) between 1966 and March 2018. A meta-analysis was conducted according to the methods recommended by the Cochrane Collaboration.

RESULTS

Six RCTs consisting of 176 patients were selected. Meta-analysis results showed that additional ITI had a significant advantage in terms of stricture rate and required ED sessions. Surgery-related and non-surgery-related strictures showed similar results. Additional ITI was not associated with significantly increased risk of complications.

CONCLUSIONS

Our meta-analysis showed that additional ITI therapy was supposed to be effective and safe for benign esophageal strictures as it reduced the stricture rate and required ED sessions. However, more RCTs are necessary to support these findings.

摘要

目的

评估内镜下病灶内注射曲安奈德（ITI）联合内镜扩张（ED）治疗良性食管狭窄的疗效和安全性。

方法

全面检索包括MEDLINE、EMBASE、Cochrane图书馆和科学网在内的在线数据库，查找1966年至2018年3月期间的前瞻性随机对照试验（RCT）。根据Cochrane协作网推荐的方法进行荟萃分析。

结果

选取了6项RCT，共176例患者。荟萃分析结果显示，额外进行ITI在狭窄率和所需的内镜扩张次数方面具有显著优势。手术相关和非手术相关的狭窄显示出相似的结果。额外进行ITI与并发症风险显著增加无关。

结论

我们的荟萃分析表明，额外进行ITI治疗对良性食管狭窄有效且安全，因为它降低了狭窄率并减少了所需的内镜扩张次数。然而，需要更多的RCT来支持这些发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3df/6109539/82f923463fd5/GRP2018-7619298.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3df/6109539/8fd22e30ad0f/GRP2018-7619298.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3df/6109539/a050e0210412/GRP2018-7619298.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3df/6109539/0c21e0b65054/GRP2018-7619298.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3df/6109539/7860064c64f3/GRP2018-7619298.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3df/6109539/a9d517e9541d/GRP2018-7619298.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3df/6109539/82f923463fd5/GRP2018-7619298.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3df/6109539/8fd22e30ad0f/GRP2018-7619298.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3df/6109539/a050e0210412/GRP2018-7619298.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3df/6109539/0c21e0b65054/GRP2018-7619298.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3df/6109539/7860064c64f3/GRP2018-7619298.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3df/6109539/a9d517e9541d/GRP2018-7619298.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3df/6109539/82f923463fd5/GRP2018-7619298.006.jpg

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