内镜下病灶内注射曲安奈德治疗良性食管狭窄的疗效与安全性

Efficacy and Safety of Endoscopic Intralesional Triamcinolone Injection for Benign Esophageal Strictures.

作者信息

Zhang Ya-Wu, Wei Feng-Xian, Qi Xue-Ping, Liu Zhao, Xu Xiao-Dong, Zhang You-Cheng

机构信息

Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730000, China.

Hepato-Biliary-Pancreatic Institute, Lanzhou University Second Hospital, Lanzhou 730000, China.

出版信息

Gastroenterol Res Pract. 2018 Aug 6;2018:7619298. doi: 10.1155/2018/7619298. eCollection 2018.

OBJECTIVES

To evaluate the efficacy and safety of endoscopic intralesional triamcinolone injection (ITI) for benign esophageal strictures combined with endoscopic dilation (ED).

METHODS

Online databases including MEDLINE, EMBASE, the Cochrane Library, and Web of Science were comprehensively searched for prospective randomized control trials (RCTs) between 1966 and March 2018. A meta-analysis was conducted according to the methods recommended by the Cochrane Collaboration.

RESULTS

Six RCTs consisting of 176 patients were selected. Meta-analysis results showed that additional ITI had a significant advantage in terms of stricture rate and required ED sessions. Surgery-related and non-surgery-related strictures showed similar results. Additional ITI was not associated with significantly increased risk of complications.

CONCLUSIONS

Our meta-analysis showed that additional ITI therapy was supposed to be effective and safe for benign esophageal strictures as it reduced the stricture rate and required ED sessions. However, more RCTs are necessary to support these findings.