首发未用药的帕金森病患者运动亚型的精神科特征。
Psychiatric profile of motor subtypes of de novo drug-naïve Parkinson's disease patients.
机构信息
Centro Fermi - Museo Storico della Fisica e Centro Studi e Ricerche "Enrico Fermi", Rome, Italy.
Fondazione Santa Lucia IRCCS, Rome, Italy.
出版信息
Brain Behav. 2018 Oct;8(10):e01094. doi: 10.1002/brb3.1094. Epub 2018 Aug 30.
BACKGROUND
Parkinson's disease (PD) is a heterogeneous neurodegenerative disorder. It is well established that different motor subtypes of PD evolve with different clinical courses and prognoses. The complete psychiatric profile underlying these different phenotypes since the very early stage of the disease is debated.
AIMS OF THE STUDY
We aimed at investigating the psychiatric profile of the three motor subtypes of PD (akinetic-rigid, tremor-dominant, and mixed) in de novo drug-naïve patients with PD.
METHODS
Sixty-eight patients with PD, divided into 39 akinetic-rigid (AR), seven mixed (MIX), and 22 tremor-dominant (TD) patients underwent a complete assessment of psychiatric, cognitive, and motor symptoms.
RESULTS
No significant differences were found among groups.
CONCLUSIONS
Our results suggest that a differentiation of the psychiatric symptoms associated with specific motor subtypes of PD is not detectable in de novo drug-naïve patients. Previous evidence that emerges later along the disease progression may be a consequence of the dopaminergic and nondopaminergic damage increase.
背景
帕金森病（PD）是一种异质性神经退行性疾病。已经证实，PD 的不同运动亚型具有不同的临床病程和预后。自疾病早期开始，这些不同表型背后的完整精神科特征仍存在争议。
研究目的
我们旨在研究新发、未经药物治疗的 PD 患者中三种运动亚型（无动性僵硬型、震颤主导型和混合型）的精神科特征。
方法
68 名 PD 患者，分为 39 名无动性僵硬型（AR）、7 名混合型（MIX）和 22 名震颤主导型（TD）患者，接受了全面的精神、认知和运动症状评估。
结果
各组之间无显著差异。
结论
我们的结果表明，在新发、未经药物治疗的患者中，无法检测到与特定运动亚型相关的精神症状的差异。之前在疾病进展过程中出现的证据可能是多巴胺能和非多巴胺能损伤增加的结果。
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