Khachanova N V
Pirogov Russian National Research Medical University, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(8. Vyp. 2):18-22. doi: 10.17116/jnevro201811808218.
The emergence of modern methods of immunohistochemistry and further development of MRI has led to a deeper understanding of gray matter (GM) pathology in multiple sclerosis (MS). GM involvement can be extensive including both demyelination (cortical lesions) and neuroaxonal damage. The mechanisms of GM damage in MS remain insufficiently studied. There are two concepts: the lesion of GM is primary and is paralleled by changes in white matter (WM), or secondary, i.e. it is a consequence of the pathological process in WM. More research into GM pathology using the latest MRI techniques will contribute to the understanding of pathological changes in both cortical and subcortical GM.
免疫组织化学现代方法的出现以及磁共振成像（MRI）的进一步发展，使人们对多发性硬化症（MS）中的灰质（GM）病理学有了更深入的了解。GM受累可能广泛，包括脱髓鞘（皮质病变）和神经轴突损伤。MS中GM损伤的机制仍研究不足。有两种观点：GM损伤是原发性的，与白质（WM）的变化平行，或者是继发性的，即它是WM病理过程的结果。使用最新MRI技术对GM病理学进行更多研究将有助于理解皮质和皮质下GM的病理变化。
