[肥胖男性精浆锌α-2糖蛋白与精液质量的相关性]

[Correlation of seminal plasma zinc alpha-2 glycoprotein with semen quality in obese males].

作者信息

Qi Ya-Nan, Ma Jing, Han Rui-Yu, Ma Jing, Wang Shu-Song

机构信息

Graduate School, Hebei Medical University, Shijiazhuang, Hebei 050017, China.

Hebei Research Institute of Family Planning Science and Technology / Key Laboratory of the National Commission of Health and Family Planning for Family Planning and Healthy Birth, Shijiazhuang, Hebei 050071, China.

出版信息

Zhonghua Nan Ke Xue. 2018 Mar;24(3):216-220.

PMID:30161306

Abstract

OBJECTIVE

To investigate the relationship between seminal plasma zinc alpha-2 glycoprotein (ZAG) and semen quality in obese males.

METHODS

This study included 130 obese male patients with idiopathic infertility Based on the concentration of seminal plasma ZAG, we divided the patients into three tertile groups: tertile 1 (T1, 73.45－97.15 μg/ml, n = 43), T2 (97.16－115.46 μg/ml, n = 44), and T3 (115.47－220.11 μg/ml, n = 43). We measured the concentrations of seminal plasma zinc (SPZ) and ZAG of the patients by ELISA, obtained the semen parameters, and analyzed the correlation of semen quality with the levels of SPZ and ZAG and the influence of obesity on SPZ, ZAG and semen quality.

RESULTS

The mean level of seminal plasma ZAG in the 130 obese male patients was (111.29 ± 26.50) μg/ml. There were statistically significant differences in sperm concentration and total sperm count among the three tertile groups (P < 0.05). The level of seminal plasma ZAG was correlated negatively with the body mass index (BMI), waist circumference (WC), sperm concentration and sperm count (P < 0.01), that of SPZ positively with BMI and WC (P < 0.05) but negatively with semen volume and the percentage of progressively motile sperm (P < 0.05). The level of serum ZAG, however, exhibited no correlation with SPZ, seminal plasma ZAG or semen quality. Obesity was found to be associated with significantly decreased concentration of seminal plasma ZAG and percentage of progressively motile sperm but remarkably increased level of SPZ (P < 0.05).

CONCLUSIONS

Obesity may induce the metabolic disorder of SPZ and ZAG, change the microenvironment of seminal plasma, and consequently affect semen quality.

摘要

目的

探讨肥胖男性精浆锌α-2糖蛋白（ZAG）与精液质量之间的关系。

方法

本研究纳入130例肥胖男性特发性不育患者。根据精浆ZAG浓度，将患者分为三个三分位数组：第1三分位数组（T1，73.45－97.15μg/ml，n = 43）、T2（97.16－115.46μg/ml，n = 44）和T3（115.47－220.11μg/ml，n = 43）。采用酶联免疫吸附测定法（ELISA）检测患者精浆锌（SPZ）和ZAG浓度，获取精液参数，并分析精液质量与SPZ、ZAG水平的相关性以及肥胖对SPZ、ZAG和精液质量的影响。

结果

130例肥胖男性患者精浆ZAG平均水平为（111.29±26.50）μg/ml。三个三分位数组之间的精子浓度和精子总数存在统计学显著差异（P<0.05）。精浆ZAG水平与体重指数（BMI）、腰围（WC）、精子浓度和精子数量呈负相关（P<0.01），SPZ水平与BMI和WC呈正相关（P<0.05），但与精液体积和进行性运动精子百分比呈负相关（P<0.05）。然而，血清ZAG水平与SPZ、精浆ZAG或精液质量无相关性。发现肥胖与精浆ZAG浓度和进行性运动精子百分比显著降低但SPZ水平显著升高有关（P<0.05）。