Geng Hao, Zhang Xian-Sheng
Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.
Zhonghua Nan Ke Xue. 2018 Mar;24(3):268-271.
Premature ejaculation (PE), as one of the most common male sexual dysfunctions, has a serious negative impact on the sexual satisfaction of the patients and their sexual partners. Lifelong PE is a most common type and a current focus of research as well. The etiology and pathogenesis of this disease are not yet clear and genetic factors are considered to be closely related to lifelong PE. Studies show that the 5-hydroxytryptamine transporter (5-HTT) gene plays an important role in the development and progression of lifelong premature ejaculation and the 5-HTT-linked polymorphic region (5-HTTLPR) has attracted much attention in recent years. This article presents an overview on the correlation between 5-HTTLPR and lifelong PE.
早泄（PE）作为最常见的男性性功能障碍之一，对患者及其性伴侣的性满意度有严重负面影响。终身性早泄是最常见的类型，也是当前的研究热点。该病的病因和发病机制尚不清楚，遗传因素被认为与终身性早泄密切相关。研究表明，5-羟色胺转运体（5-HTT）基因在终身性早泄的发生和发展中起重要作用，5-HTT连锁多态性区域（5-HTTLPR）近年来备受关注。本文综述了5-HTTLPR与终身性早泄之间的相关性。
