Nicholas M K, Bania M B, Reder A T, Joseph L, Antel J P
J Clin Lab Immunol. 1986 Jun;20(2):51-5.
In the normal young adult population, in vitro levels of polyclonally-induced IgG secretion by mononuclear cells (MNCs) vary widely amongst individuals. Levels of IgG secretion correlate with functional suppressor activity of T8+ cells but not with their proportion within the MNCs either prior to culture, or as found in this study, at the end of the culture period. The current study also demonstrates a lack of correlation between T8+ cell-mediated suppressor (Ts) function and a second predominantly T8+ cell-mediated function, alloantigen-directed cytolytic (Tc) activity. Whether this dissociation between Ts and Tc functions reflects quantitative differences in subsets contained within the T8+ population or qualitative differences in the mechanisms required for induction or generation of Ts and Tc remains to be established.
在正常年轻成年人群体中，单核细胞（MNCs）多克隆诱导的IgG分泌的体外水平在个体间差异很大。IgG分泌水平与T8 + 细胞的功能性抑制活性相关，但与培养前MNCs中它们的比例无关，或者如本研究中所发现的，与培养期结束时的比例无关。当前研究还表明，T8 + 细胞介导的抑制（Ts）功能与第二种主要由T8 + 细胞介导的功能，同种异体抗原导向的溶细胞（Tc）活性之间缺乏相关性。Ts和Tc功能之间的这种分离是反映T8 + 群体中所含亚群的数量差异，还是反映诱导或产生Ts和Tc所需机制的质量差异，仍有待确定。
