Schilbach Katharina, Junnila Riia Karoliina, Bidlingmaier Martin
Endocrine Research Unit, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, München, Germany.
Laboratory for Molecular Pharmacology, Departement of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Exp Clin Endocrinol Diabetes. 2019 Feb;127(2-03):84-92. doi: 10.1055/a-0672-0836. Epub 2018 Aug 30.
Primary aldosteronism (PA) is a severe and often underdiagnosed form of secondary hypertension. Determining the aldosterone to renin ratio (ARR) in hypertensive patients has been shown to be a valuable screening test for identification of patients suffering from PA. Since the introduction of a more widespread ARR screening the number of PA patients significantly increased worldwide. Interpretation of ARR might be challenging: Several factors from posture to interfering drugs affect the ARR and need to be taken into account when collecting samples. In addition, the wide variety of available assay methods and lack of well-established cut-offs present a challenge to the clinician. This review discusses the usefulness and possible difficulties of ARR screening.
原发性醛固酮增多症（PA）是继发性高血压的一种严重且常被漏诊的形式。已证明测定高血压患者的醛固酮与肾素比值（ARR）是识别PA患者的一项有价值的筛查试验。自从更广泛地开展ARR筛查以来，全球PA患者的数量显著增加。ARR的解读可能具有挑战性：从体位到干扰药物等多种因素都会影响ARR，在采集样本时需要考虑这些因素。此外，可用的检测方法种类繁多且缺乏公认的临界值，这给临床医生带来了挑战。本综述讨论了ARR筛查的有用性及可能存在的困难。
