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尼泊尔加德满都的肝炎病毒：一项基于医院的研究。

Hepatitis viruses in Kathmandu, Nepal: hospital-based study.

作者信息

Gupta Birendra Prasad, Adhikari Anurag, Chaudhary Santosh

机构信息

Central Diagnostic Laboratory and Research Centre, Kathmandu, Nepal.

Kathmandu Research Institute for Biological Science, Kathmandu, Nepal.

出版信息

BMC Res Notes. 2018 Aug 30;11(1):627. doi: 10.1186/s13104-018-3739-1.

DOI:10.1186/s13104-018-3739-1
PMID:30165899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6117890/
Abstract

OBJECTIVE

The objective of this study was to see the aetiology and outcome of sporadic acute viral hepatitis (AVH) in Kathmandu, Nepal.

RESULTS

Among 210 patients, 94 (45%) were male and 116 (55%) were female. Mean age was 30 years. 52 (24.7%) out of 210 were positive for either of the hepatitis virus infection. Major causative agent for AVH among hepatitis positive patients were hepatitis E virus (HEV) in 36 (69.2%), followed by hepatitis A virus (HAV) 8 (15.3%), hepatitis B virus (HBV) 7 (13.4%) and hepatitis C virus (HCV) 1 (1.9%). The 158 (75.3%) patient were negative for all hepatitis viral markers. Co-infections with more than one virus were found in 4 (7.6%) patients. All liver-specific enzymes including bilirubin increased in hepatitis-infected patients. We found large number circulation of HEV in Kathmandu, Nepal, indicating that this region is endemic for hepatitis virus infection.

摘要

目的

本研究的目的是了解尼泊尔加德满都散发性急性病毒性肝炎（AVH）的病因及转归。

结果

210例患者中，男性94例（45%），女性116例（55%）。平均年龄为30岁。210例中有52例（24.7%）肝炎病毒感染呈阳性。肝炎阳性患者中，AVH的主要病原体为戊型肝炎病毒（HEV）36例（69.2%），其次是甲型肝炎病毒（HAV）8例（15.3%）、乙型肝炎病毒（HBV）7例（13.4%）和丙型肝炎病毒（HCV）1例（1.9%）。158例（75.3%）患者所有肝炎病毒标志物均为阴性。4例（7.6%）患者存在多种病毒合并感染。肝炎感染患者的所有肝脏特异性酶包括胆红素均升高。我们发现尼泊尔加德满都存在大量HEV循环，表明该地区为肝炎病毒感染的地方性流行区。