D-氨基酸氧化酶抑制：氯氮平增效治疗精神分裂症的新谷氨酸作用机制？ - Suppr

D-Amino Acid Oxidase Inhibition: A New Glutamate Twist for Clozapine Augmentation in Schizophrenia?

作者信息

Harrison Paul J

机构信息

Department of Psychiatry, University of Oxford, and Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, United Kingdom.

出版信息

Biol Psychiatry. 2018 Sep 15;84(6):396-398. doi: 10.1016/j.biopsych.2018.06.001.

DOI:10.1016/j.biopsych.2018.06.001

PMID:30165950

Abstract

摘要

相似文献

D-Amino Acid Oxidase Inhibition: A New Glutamate Twist for Clozapine Augmentation in Schizophrenia?D-氨基酸氧化酶抑制：氯氮平增效治疗精神分裂症的新谷氨酸作用机制？

Biol Psychiatry. 2018 Sep 15;84(6):396-398. doi: 10.1016/j.biopsych.2018.06.001.

Sodium Benzoate, a D-Amino Acid Oxidase Inhibitor, Added to Clozapine for the Treatment of Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Trial.苯甲酸钠，一种 D-氨基酸氧化酶抑制剂，添加到氯氮平中治疗精神分裂症：一项随机、双盲、安慰剂对照试验。

Biol Psychiatry. 2018 Sep 15;84(6):422-432. doi: 10.1016/j.biopsych.2017.12.006. Epub 2017 Dec 26.

Novel Treatment for the Most Resistant Schizophrenia: Dual Activation of NMDA Receptor and Antioxidant.新型治疗最顽固精神分裂症的方法：NMDA 受体和抗氧化剂双重激活。

Curr Drug Targets. 2020;21(6):610-615. doi: 10.2174/1389450120666191011163539.

Sodium benzoate: A novel multi-target pharmaceutical approach to rescue clozapine-resistant schizophrenia.苯甲酸钠：一种治疗氯氮平抵抗性精神分裂症的新型多靶点药物疗法。

Schizophr Res. 2024 Jun;268:261-264. doi: 10.1016/j.schres.2023.05.001. Epub 2023 May 24.

Add-on treatment of benzoate for schizophrenia: a randomized, double-blind, placebo-controlled trial of D-amino acid oxidase inhibitor.苯甲酸盐辅助治疗精神分裂症：D-氨基酸氧化酶抑制剂的随机、双盲、安慰剂对照试验。

JAMA Psychiatry. 2013 Dec;70(12):1267-75. doi: 10.1001/jamapsychiatry.2013.2159.

Clozapine augmented with glutamate modulators in refractory schizophrenia: a review and metaanalysis.难治性精神分裂症中联合谷氨酸调节剂使用氯氮平：一项综述与荟萃分析

Pharmacopsychiatry. 2014 Sep;47(6):185-94. doi: 10.1055/s-0034-1383656. Epub 2014 Jul 7.

Higher serum concentrations of tyrosine and glutamate in schizophrenia patients treated with clozapine, compared to in those treated with conventional antipsychotics.与接受传统抗精神病药物治疗的精神分裂症患者相比，接受氯氮平治疗的患者血清中酪氨酸和谷氨酸浓度更高。

Neuro Endocrinol Lett. 2015;36(5):465-80.

Augmentation Strategies for Clozapine-Resistant Patients with Schizophrenia.增效策略治疗氯氮平抵抗的精神分裂症患者

Curr Pharm Des. 2020;26(2):218-227. doi: 10.2174/1381612826666200110102254.

Determination of D-serine and D-alanine Tissue Levels in the Prefrontal Cortex and Hippocampus of Rats After a Single Dose of Sodium Benzoate, a D-Amino Acid Oxidase Inhibitor, with Potential Antipsychotic and Antidepressant Properties.测定单剂量苯甲酸钠（一种具有潜在抗精神病和抗抑郁特性的 D-氨基酸氧化酶抑制剂）后大鼠前额叶皮层和海马中的 D-丝氨酸和 D-丙氨酸组织水平。

Neurochem Res. 2023 Jul;48(7):2066-2076. doi: 10.1007/s11064-023-03884-1. Epub 2023 Feb 14.

Amisulpride augmentation in clozapine-unresponsive schizophrenia (AMICUS): a double-blind, placebo-controlled, randomised trial of clinical effectiveness and cost-effectiveness.氨磺必利增效氯氮平治疗精神分裂症无效患者（AMICUS）：一项双盲、安慰剂对照、随机临床试验，评估临床疗效和成本效益。

Health Technol Assess. 2017 Sep;21(49):1-56. doi: 10.3310/hta21490.

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Interpretable machine learning to evaluate relationships between DAO/DAOA (pLG72) protein data and features in clinical assessments, functional outcome, and cognitive function in schizophrenia patients.可解释的机器学习，用于评估精神分裂症患者中DAO/DAOA（pLG72）蛋白数据与临床评估、功能结局及认知功能特征之间的关系。

Schizophrenia (Heidelb). 2025 Feb 22;11(1):27. doi: 10.1038/s41537-024-00548-z.

Targeting D-Amino Acid Oxidase (DAAO) for the Treatment of Schizophrenia: Rationale and Current Status of Research.靶向 D-氨基酸氧化酶（DAAO）治疗精神分裂症：原理和研究现状。

CNS Drugs. 2022 Nov;36(11):1143-1153. doi: 10.1007/s40263-022-00959-5. Epub 2022 Oct 4.

Diagnosing Alzheimer's Disease Specifically and Sensitively With pLG72 and Cystine/Glutamate Antiporter SLC7A11 AS Blood Biomarkers.利用 pLG72 和胱氨酸/谷氨酸反向转运蛋白 SLC7A11 作为血液生物标志物特异性和敏感地诊断阿尔茨海默病。

Int J Neuropsychopharmacol. 2023 Jan 19;26(1):1-8. doi: 10.1093/ijnp/pyac053.

Rational and Translational Implications of D-Amino Acids for Treatment-Resistant Schizophrenia: From Neurobiology to the Clinics.D-氨基酸治疗抵抗性精神分裂症的合理性和转化意义：从神经生物学到临床。

Biomolecules. 2022 Jun 29;12(7):909. doi: 10.3390/biom12070909.

Effects of Sodium Benzoate, a D-Amino Acid Oxidase Inhibitor, on Perceived Stress and Cognitive Function Among Patients With Late-Life Depression: A Randomized, Double-Blind, Sertraline- and Placebo-Controlled Trial.苯甲酸钠（一种 D-氨基酸氧化酶抑制剂）对老年期抑郁症患者的感知压力和认知功能的影响：一项随机、双盲、舍曲林和安慰剂对照试验。

Int J Neuropsychopharmacol. 2022 Aug 4;25(7):545-555. doi: 10.1093/ijnp/pyac006.

Effect of Sodium Benzoate on Cognitive Function Among Patients With Behavioral and Psychological Symptoms of Dementia: Secondary Analysis of a Randomized Clinical Trial.苯甲酸钠对痴呆患者行为和心理症状认知功能的影响：一项随机临床试验的二次分析。

JAMA Netw Open. 2021 Apr 1;4(4):e216156. doi: 10.1001/jamanetworkopen.2021.6156.

Precision Medicine of Sodium Benzoate for the Treatment of Behavioral and Psychological Symptoms of Dementia (BPSD).苯甲酸钠治疗痴呆行为和心理症状（BPSD）的精准医学

Neuropsychiatr Dis Treat. 2020 Feb 20;16:509-518. doi: 10.2147/NDT.S234371. eCollection 2020.

Early Identification and Intervention of Schizophrenia: Insight From Hypotheses of Glutamate Dysfunction and Oxidative Stress.精神分裂症的早期识别与干预：来自谷氨酸功能障碍和氧化应激假说的见解

Front Psychiatry. 2019 Feb 27;10:93. doi: 10.3389/fpsyt.2019.00093. eCollection 2019.

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D-Amino Acid Oxidase Inhibition: A New Glutamate Twist for Clozapine Augmentation in Schizophrenia?

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