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[免疫检查点抑制剂的肿瘤评估标准]

[Tumour assessment criteria for immune checkpoint inhibitors].

作者信息

Wasielewski E, Cortot A B

机构信息

Service de pneumologie et oncologie thoracique, université de Lille, hôpital Calmette, OncoLille, CHRU de Lille, boulevard Professeur-Jules-Leclercq, 59037 Lille, France.

Service de pneumologie et oncologie thoracique, université de Lille, hôpital Calmette, OncoLille, CHRU de Lille, boulevard Professeur-Jules-Leclercq, 59037 Lille, France.

出版信息

Rev Mal Respir. 2018 Oct;35(8):828-845. doi: 10.1016/j.rmr.2017.06.007. Epub 2018 Aug 27.

Abstract

The development of immune checkpoint inhibitors in thoracic oncology has led to a reconsideration of the rules for radiological tumor assessment. The RECIST criteria are widely used for the assessment of conventional treatments but are not suitable for anti-tumoral immunotherapy. The mechanism of action of this new class of drugs may induce specific patterns of response, which are not fully assessed by the RECIST criteria. Several new criteria have been proposed to better detect these patterns of response. The changes usually include confirmation of progression, new ways of assessing new lesions, and a larger role for clinical assessment. Nevertheless, harmonization and validation of these criteria remains indispensable. In this review, we will detail the different criteria that are currently available, and discuss their strengths and weaknesses.

摘要

免疫检查点抑制剂在胸部肿瘤学中的发展促使人们重新审视放射学肿瘤评估规则。实体瘤疗效评价标准(RECIST)广泛用于传统治疗的评估,但不适用于抗肿瘤免疫治疗。这类新型药物的作用机制可能会诱导特定的反应模式,而RECIST标准无法对其进行全面评估。为了更好地检测这些反应模式,人们提出了几种新标准。这些变化通常包括进展的确认、评估新病灶的新方法以及临床评估发挥更大作用。然而,这些标准的统一和验证仍然必不可少。在本综述中,我们将详细介绍目前可用的不同标准,并讨论它们的优缺点。

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