Department of Diabetes, Central Clinical School, Monash University, Australia.
Department of Diabetes, Central Clinical School, Monash University, Australia
Clin Sci (Lond). 2018 Aug 30;132(16):1811-1836. doi: 10.1042/CS20171459. Print 2018 Aug 31.
Chronic renal and vascular oxidative stress in association with an enhanced inflammatory burden are determinant processes in the development and progression of diabetic complications including cardiovascular disease (CVD), atherosclerosis and diabetic kidney disease (DKD). Persistent hyperglycaemia in diabetes mellitus increases the production of reactive oxygen species (ROS) and activates mediators of inflammation as well as suppresses antioxidant defence mechanisms ultimately contributing to oxidative stress which leads to vascular and renal injury in diabetes. Furthermore, there is increasing evidence that ROS, inflammation and fibrosis promote each other and are part of a vicious connection leading to development and progression of CVD and kidney disease in diabetes.
慢性肾血管氧化应激与炎症负担增加是糖尿病并发症发展和进展的决定因素，包括心血管疾病 (CVD)、动脉粥样硬化和糖尿病肾病 (DKD)。糖尿病患者持续高血糖会增加活性氧 (ROS) 的产生，并激活炎症介质，同时抑制抗氧化防御机制，最终导致氧化应激，导致糖尿病患者的血管和肾脏损伤。此外，越来越多的证据表明，ROS、炎症和纤维化相互促进，形成一个恶性循环，导致糖尿病患者心血管疾病和肾脏疾病的发生和发展。
