根据激素/受体/效应器模型对促性腺激素释放激素、相关肽及白三烯C4诱导促黄体生成素释放的剂量反应曲线的解读
Interpretation of dose-response curves for luteinizing hormone release by gonadotropin-releasing hormone, related peptides, and leukotriene C4 according to a hormone/receptor/effector model.
作者信息
Leiser J, Conn P M, Blum J J
出版信息
Proc Natl Acad Sci U S A. 1986 Aug;83(16):5963-7. doi: 10.1073/pnas.83.16.5963.
Abstract
The dose-response curves for pituitary luteinizing hormone (LH) release in response to gonadotropin-releasing hormone and its agonists are unusually broad. It appears, however, that these ligands bind to a single class of receptors. It is shown that these dose-response data can be explained by either of two models in which ligand-receptor complexes stimulate LH secretion by interacting with either of two different effector systems or by interacting with a single effector system but forming monomeric and dimeric active effector complexes. A combination of these two basic models can account for the very broad, biphasic dose-response curve reported for LH release in response to leukotriene C4.
摘要
垂体促黄体生成素（LH）释放对促性腺激素释放激素及其激动剂的剂量-反应曲线异常宽泛。然而，这些配体似乎与单一类别的受体结合。研究表明，这些剂量-反应数据可以用两种模型中的任何一种来解释，在这两种模型中，配体-受体复合物通过与两种不同的效应系统之一相互作用，或与单一效应系统相互作用但形成单体和二聚体活性效应复合物来刺激LH分泌。这两种基本模型的结合可以解释白三烯C4刺激LH释放所报告的非常宽泛的双相剂量-反应曲线。
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