Leinonen L, Stenberg D
Physiol Behav. 1986;37(2):199-202. doi: 10.1016/0031-9384(86)90221-0.
Polygraphic (EEG, EOG, EMG) 12-hr recordings were made in 3 adult monkeys (Macaca arctoides) to document their normal sleep pattern and to examine the effects of prazosin, an alpha-1-adrenoceptor antagonist. In comparison to man, REM episodes appeared at shorter intervals (50 min) and they always ended in movement arousal or waking up. As in man the proportion of deep sleep decreased and the proportion of REM sleep increased towards morning. During eight hours after parenteral administration of prazosin, at doses without any noticeable behavioral side effects, the number of REM episodes and the amount of REM sleep was 30 to 80 percent greater than during the control nights. The changes were statistically nonsignificant. However, since the results were similar in all three monkeys, it can be suggested that prazosin had some effect on the cyclicity of sleep. Dose 1 mg/kg resulted in behavioral side effects and disturbed sleep.
对3只成年熊猴（熊猴）进行了12小时的多导睡眠图（脑电图、眼电图、肌电图）记录，以记录其正常睡眠模式，并研究α-1肾上腺素能受体拮抗剂哌唑嗪的作用。与人类相比，快速眼动睡眠期出现的间隔较短（50分钟），且总是以运动觉醒或醒来结束。与人类一样，深度睡眠的比例降低，快速眼动睡眠的比例在接近早晨时增加。在肠胃外给予哌唑嗪后8小时内，在没有任何明显行为副作用的剂量下，快速眼动睡眠期的数量和快速眼动睡眠时间比对照夜晚增加了30%至80%。这些变化在统计学上无显著意义。然而，由于所有三只猴子的结果相似，可以认为哌唑嗪对睡眠周期有一定影响。1mg/kg的剂量导致行为副作用和睡眠紊乱。
