婴儿慢性荨麻疹作为自身炎症性疾病的首发表现
Chronic urticaria in infants as the first manifestation of autoinflammatory disease.
作者信息
Latour Irene, Noguera-Morel Lucero, Colmenero Isabel, Clemente Daniel, Hernández-Martín Angela, López-Robledillo Juan Carlos, Arostegui Juan I, Torrelo Antonio
机构信息
Department of Dermatology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
Department of Pathology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
出版信息
Pediatr Dermatol. 2018 Nov;35(6):e337-e340. doi: 10.1111/pde.13619. Epub 2018 Aug 30.
We report two unrelated infants in whom chronic urticaria was the first clinical manifestation of cryopyrin-associated periodic syndrome, which should be suspected in infants with early-onset chronic urticaria, especially if there is a neutrophil-rich infiltrate in the skin biopsy. Early diagnosis of cryopyrin-associated periodic syndrome may lead to early and successful treatment with anti-interleukin-1 medications.
我们报告了两名无血缘关系的婴儿，在他们身上，慢性荨麻疹是冷吡啉相关周期性综合征的首发临床表现。对于早发性慢性荨麻疹的婴儿，尤其是皮肤活检中有富含中性粒细胞浸润的情况，应怀疑患有该病。冷吡啉相关周期性综合征的早期诊断可能会带来使用抗白细胞介素-1药物进行早期且成功的治疗。
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