Key Laboratory of Chemical Biology of Jiangxi Province, College of Chemistry and Chemical Engineering , Jiangxi Normal University , Nanchang , 330022 Jiangxi , People's Republic of China.
Org Lett. 2018 Sep 21;20(18):5688-5691. doi: 10.1021/acs.orglett.8b02409. Epub 2018 Aug 31.
An efficient intermolecular trans-selective β-hydroamidation of ynamides to furnish a series of ( Z)-ethene-1,2-diamide derivatives with excellent regio- and stereo-selectivities is described. The trans-β-addition reactions have been illustrated for a wide range of substrates and proceeded under basic reaction conditions using readily available materials in the absence of a transition-metal catalyst. The synthetic approach to these novel ( Z)-ethene-1,2-diamide derivatives paves the way for further exploration of their synthetic application.
本文描述了一种有效的炔酰胺分子间反式选择性β-氢酰胺化反应，能够以优异的区域和立体选择性得到一系列（Z）-乙烯-1,2-二酰胺衍生物。反式-β-加成反应适用于广泛的底物，并在碱性反应条件下，使用易得的材料，无需过渡金属催化剂即可进行。这些新型（Z）-乙烯-1,2-二酰胺衍生物的合成方法为进一步探索其合成应用奠定了基础。
