Chin H W, Maruyama Y, Young B, Markesbery W, Tibbs P, Goldstein S
Strahlenther Onkol. 1986 Jul;162(7):433-6.
A clinical trial with neutron brachytherapy for malignant glioma is now in progress at the University of Kentucky Medical Center. In the initial three year period, 32 patients entered the study. There were 24 males and eight females, and the peak incidence was seen in the seventh decade. All patients underwent surgical resection of tumor followed by Cf-252 implantation and external radiotherapy. The implantation procedure was well tolerated by the patients and demonstrated a short-term benefit in survival of patients who were able to complete planned radiotherapy. Older patients had less tolerance to radiotherapy. The evaluation of the beneficial effects of Cf-252 brachytherapy will require patients who are able to tolerate the whole course of therapy.
肯塔基大学医学中心目前正在进行一项关于中子近距离治疗恶性胶质瘤的临床试验。在最初的三年里，有32名患者进入该研究。其中男性24名，女性8名，发病高峰出现在70岁年龄段。所有患者均接受了肿瘤手术切除，随后进行了Cf - 252植入和外照射放疗。患者对植入过程耐受性良好，对于能够完成计划放疗的患者，该治疗在短期生存方面显示出益处。老年患者对放疗的耐受性较差。对Cf - 252近距离治疗的有益效果评估将需要能够耐受整个疗程的患者。
