在染色质中启动碱基切除修复。
Initiating base excision repair in chromatin.
机构信息
Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912, United States.
Department of Chemistry, Brown University, Providence, RI 02912, United States.
出版信息
DNA Repair (Amst). 2018 Nov;71:87-92. doi: 10.1016/j.dnarep.2018.08.011. Epub 2018 Aug 24.
Abstract
The base excision repair (BER) pathway removes modified nucleobases that can be deleterious to an organism. BER is initiated by a glycosylase, which finds and removes these modified nucleobases. Most of the characterization of glycosylase activity has been conducted in the context of DNA oligomer substrates. However, DNA within eukaryotic organisms exists in a packaged environment with the basic unit of organization being the nucleosome core particle (NCP). The NCP is a complex substrate for repair in which a variety of factors can influence glycosylase activity. In this Review, we focus on the geometric positioning of modified nucleobases in an NCP and the consequences on glycosylase activity and initiating BER.
摘要
碱基切除修复（BER）途径可去除对生物体有害的修饰碱基。BER 由糖苷酶起始，该酶可发现并去除这些修饰碱基。糖苷酶活性的大部分特征已在 DNA 寡聚体底物的背景下进行了研究。然而，真核生物中的 DNA 存在于一个被包装的环境中，其基本组织单元是核小体核心颗粒（NCP）。NCP 是一种复杂的修复底物，其中各种因素会影响糖苷酶的活性。在这篇综述中，我们专注于修饰碱基在 NCP 中的几何定位以及对糖苷酶活性和起始 BER 的影响。
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